[11C]Cyanation of arylboronic acids in aqueous solutions. Issue 49 (5th June 2017)

• Record Type: Journal Article
• Authors: Ma, Longle; Placzek, Michael S.; Hooker, Jacob M.; Vasdev, Neil; Liang, Steven H.
• Is Part Of: Chemical communications. Volume 53:Issue 49(2017)
• Page Start: 6597
• Page End: 6600
• Publication Date: 2017-06-05
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc02886e
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A copper-mediated 11 C-cyanation method employing arylboronic acids and [ 11 C]HCN in aqueous solutions has been developed to provide a wide range of aromatic 11 C-nitriles. Abstract : A copper-mediated 11 C-cyanation method employing arylboronic acids and [ 11 C]HCN has been developed. This method was applied to the radiochemical synthesis of a wide range of aromatic 11 C-nitriles in aqueous solutions. The use of readily accessible arylboronic acids as precursors makes this method complementary to the well-established 11 C-cyanation methods that utilize aryl halide precursors.