Nanomedicine: In Vivo Gene‐Silencing in Fibrotic Liver by siRNA‐Loaded Cationic Nanohydrogel Particles (Adv. Healthcare Mater. 18/2015). Issue 18 (December 2015)

• Record Type: Journal Article
• Authors: Kaps, Leonard; Nuhn, Lutz; Aslam, Misbah; Brose, Alexander; Foerster, Friedrich; Rosigkeit, Sebastian; Renz, Patricia; Heck, Rosario; Kim, Yong Ook; Lieberwirth, Ingo; Schuppan, Detlef; Zentel, Rudolf
• Is Part Of: Advanced healthcare materials. Volume 4:Issue 18(2015)
• Page Start: 2737
• Page End: 2737
• Publication Date: 2015-12
• Subjects: cationic nanohydrogels -- in vivo gene knockdown -- liver fibrosis -- nanogels -- siRNA delivery; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201570101
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : Knocking down collagen synthesis in liver fibrosis: On page 2809, D. Schuppan, R. Zentel, and co‐workers show how systemically administered cationic nanohydrogel particles loaded with anti‐Col1α1 siRNA target fibrogenic effector cells in the liver and thereby suppress collagen synthesis and attenuate fibrosis (Cover design: Cristina Sala).