Photomediated Reactive Oxygen Species‐Generable Nanoparticles for Triggered Release and Endo/Lysosomal Escape of Drug upon Attenuated Single Light Irradiation. Issue 18 (9th October 2015)

• Record Type: Journal Article
• Authors: Seo, Eun Ha; Lee, Chung‐Sung; Na, Kun
• Is Part Of: Advanced healthcare materials. Volume 4:Issue 18(2015)
• Page Start: 2822
• Page End: 2830
• Publication Date: 2015-10-09
• Subjects: drug delivery -- endo/lysosomal escape -- photodynamic therapy -- reactive oxygen species -- triggered drug release; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201500622
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : Nanoparticles with "smart" stimuli‐responsive materials and multiple therapeutic strategies in a single delivery platform have emerged for highly efficient cancer therapy. Here, photomediated reactive oxygen species (ROS)‐generable nanoparticles are designed that can trigger drug release and endo/lysosomal escape upon attenuated single light irradiation, simultaneously, for synergistic chemo‐photodynamic ablation. In this study, the self‐ROS‐generable nanoparticles (SRNs) are prepared from the polymer based on polysaccharide, chlorin e6 as ROS generator and lipoic acid as ROS scavenger covalently conjugated pullulan with anticancer drug (doxorubicin, DOX) through self‐assembly, and can disassemble via the ROS‐mediated reduction of lipoyl group in response to low level exogenous single light switch. After cellular internalization in hepatic cancer through asialoglycoprotein receptor (ASGPR, as pullulan receptor)‐mediated endocytosis, once irradiated, SRNs are able to produce ROS that can simultaneously induce drug release triggering and endo/lysosomal escape of DOX into cytoplasm as well as directly photodynamic therapy for highly efficient chemo‐photodynamic cancer therapy. This promising delivery system, which has huge potential in biomedical applications, may be optimal for smart delivery platform. Abstract : Photomediated reactive oxygen species (ROS)‐generable nanoparticles (SRNs) incorporated with ROS‐generator and scavenger in a single delivery platform is developed. Under attenuated single light irradiation, doxorubicin loaded SRNs (D‐SRNs) synergistically exhibit simultaneous triggered drug release and endo/lysosomal escape as well as photodynamic therapy for highly efficient cancer treatment.