In Vivo Gene‐Silencing in Fibrotic Liver by siRNA‐Loaded Cationic Nanohydrogel Particles. Issue 18 (2nd December 2015)

• Record Type: Journal Article
• Authors: Kaps, Leonard; Nuhn, Lutz; Aslam, Misbah; Brose, Alexander; Foerster, Friedrich; Rosigkeit, Sebastian; Renz, Patricia; Heck, Rosario; Kim, Yong Ook; Lieberwirth, Ingo; Schuppan, Detlef; Zentel, Rudolf
• Is Part Of: Advanced healthcare materials. Volume 4:Issue 18(2015)
• Page Start: 2809
• Page End: 2815
• Publication Date: 2015-12-02
• Subjects: cationic nanohydrogels -- in vivo gene knockdown -- liver fibrosis -- nanogels -- siRNA delivery; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201500826
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : Cationic nanohydrogel particles loaded with anti‐Col1α1 siRNA suppress collagen synthesis and deposition in fibrotic mice : Systemically administered 40 nm sized nanogel particles accumulate in collagen‐expressing cells in the liver. Their siRNA payload induces a sequence specific in vivo gene knockdown affording an efficient antifibrotic effect in mice with liver fibrosis.