Diagnostic Efficacy and Safety of Endobronchial Ultrasound‐Guided Transbronchial Needle Aspiration in Intrathoracic Tuberculosis: A Meta‐analysis. (12th August 2015)

• Record Type: Journal Article
• Authors: Ye, Wu; Zhang, Ruifeng; Xu, Xiaoling; Liu, Yanru; Ying, Kejing
• Is Part Of: Journal of ultrasound in medicine. Volume 34:Number 9(2015)
• Page Start: 1645
• Page End: 1650
• Publication Date: 2015-08-12
• Subjects: diagnostic accuracy -- endobronchial ultrasound-guided transbronchial needle aspiration -- intrathoracic tuberculosis -- meta-analysis -- tuberculous lymphadenopathy; Ultrasonics in medicine -- Periodicals; Ultrasonics; Ultrasonography; Ultrasonics in medicine; Electronic journals; Periodicals; Periodicals; 616.07543
• DOI: 10.7863/ultra.15.14.06017
• Languages: English
• ISSNs: 0278-4297

Abstract

Abstract : Objectives: Endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA) is a minimally invasive technique. A meta‐analysis was performed to assess the efficacy and safety of EBUS‐TBNA in intrathoracic tuberculosis (TB). Methods: We searched PubMed, the Cochrane Library, and the Web of Science for suitable studies. The pooled sensitivity, specificity, likelihood ratios (LRs), and diagnostic odds ratio were calculated. A summary receiver operating characteristic (ROC) curve was constructed to calculate the area under the summary ROC curve and Q point value ( Q* ). Results: A total of 8 studies with 809 patients were included. The pooled sensitivity and specificity of EBUS‐TBNA for diagnosis of intrathoracic TB were 0.80 (95% confidence interval [CI] 0.74–0.85) and 1.00 (95% CI, 0.99–1.00), respectively. The positive LR was 38.25 (95% CI, 13.59–107.65); the negative LR was 0.24 (95% CI, 0.17–0.33); and the diagnostic odds ratio was 186.35 (95% CI, 63.57–546.28). The area under the summary ROC curve was 0.935, and the Q *was 0.871. The pooled sensitivity of EBUS‐TBNA for diagnosis of intrathoracic tuberculous lymphadenopathy was 0.87 (95% CI, 0.80–0.95). Only 1 serious complication was reported. Conclusions: Endobronchial US‐guided TBNA is an effective and safe diagnostic tool for intrathoracic TB, especially intrathoracic tuberculous lymphadenopathy.