A case of primary ciliary dyskinesia treated with ICSI using testicular spermatozoa: case report and a review of the literature. (19th May 2015) - Kawasaki, Akiko
Abstract: Purpose: To investigate whether or not intracytoplasmic sperm injection (ICSI) using spermatozoa extracted from testis (TESE‐ICSI) is a more effective treatment than ICSI with ejaculated spermatozoa (EJ‐ICSI) for primary ciliary dyskinesia (PCD). Methods: We reported a case of PCD in which we performed TESE‐ICSI after repeated failure of EJ‐ICSI. Together with data from previous case reports, we compared the fertilization rate and pregnancy outcome of TESE‐ICSI and EJ‐ICSI. Results: In our case, TESE‐ICSI improved the morphology of spermatozoa and fertilization rate. However, the outcome was only a biochemical pregnancy. According to the analysis combined with previous reports, there was no difference in the fertilization rate and pregnancy outcome parameters between TESE‐ICSI and EJ‐ICSI. Conclusions: TESE‐ICSI for PCD may improve the fertilization rate compared to EJ‐ICSI. However, it does not necessarily improve the pregnancy outcome for a patient with primary ciliary dyskinesia.