PCB 28 metabolites elimination kinetics in human plasma on a real case scenario: Study of hydroxylated polychlorinated biphenyl (OH-PCB) metabolites of PCB 28 in a highly exposed German Cohort. (5th July 2017)

• Record Type: Journal Article
• Authors: Quinete, Natalia; Esser, André; Kraus, Thomas; Schettgen, Thomas
• Is Part Of: Toxicology letters. Volume 276(2017)
• Page Start: 100
• Page End: 107
• Publication Date: 2017-07-05
• Subjects: Elimination kinetics -- Human plasma -- Occupational exposure -- Polychlorinated biphenyl metabolism pathway -- Hydroxylated polychlorinated biphenyls -- Carcinogen; Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2017.05.025
• Languages: English
• ISSNs: 0378-4274

Abstract

Highlights: Four metabolites of PCB28 were predicted and custom synthesized in the course of this study. The study was conducted in plasma samples of highly PCB-exposed individuals. PCB 28 metabolites were measured in human plasma for the first time. Half-lives for OH-metabolites of PCB 28 have been estimated for the first time. Abstract: Polychlorinated biphenyls (PCBs) are suspected of carcinogenic, neurotoxic and immunotoxic effects in animals and humans. Although background levels of PCBs have been slowly decreased after their ban, they are still among the most persistent and ubiquitous pollutants in the environment, remaining the subject of great concern. PCB 28 is a trichlorinated PCB found in high concentrations not only in human plasma but also in indoor air in Europe, yet little is known about its metabolic pathway and potential metabolites in humans. The present study aims to elucidate the kinetics of metabolite formation and elimination by analyzing four hydroxylated PCBs (OH-PCBs) in human plasma as potential metabolites of the PCB 28 congener. For this purpose, the study was conducted in plasma samples of highly PCB-exposed individuals (N = 268), collected from 2010 to 2014 as a representation of a real case scenario with longitudinal data. OH-PCBs have been predicted, synthesized in the course of this study and further identified and quantitated in human plasma. This is the first time that previously unknown PCB 28 metabolites have been measured in human plasma and half-lives have been estimated for PCB metabolites, which could then provide further understanding in the toxicological consequences of exposure to PCBs in humans.