Palladium(0)-catalyzed asymmetric C(sp3)–H arylation using a chiral binol-derived phosphate and an achiral ligand. Issue 2 (19th October 2016)

• Record Type: Journal Article
• Authors: Yang, Lei; Melot, Romain; Neuburger, Markus; Baudoin, Olivier
• Is Part Of: Chemical science. Volume 8:Issue 2(2017)
• Page Start: 1344
• Page End: 1349
• Publication Date: 2016-10-19
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6sc04006c
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : High enantioselectivities can be achieved using an appropriate chiral base/achiral ligand combination in Pd 0 -catalyzed C(sp 3 )–H activation. Abstract : The first efficient palladium(0)-catalyzed enantioselective C(sp 3 )–H activation reaction using a catalytic chiral base and an achiral phosphine ligand is reported. Fine-tuning the binol-derived phosphoric acid pre-catalyst and the reaction conditions was found to be crucial to achieve high levels of enantioselectivity for a variety of indoline products containing both tri- and tetrasubstituted stereocenters.