A palladium-catalyzed synthesis of (hetero)aryl-substituted imidazoles from aryl halides, imines and carbon monoxide. Issue 2 (8th November 2016)

• Record Type: Journal Article
• Authors: Tjutrins, Jevgenijs; Arndtsen, Bruce A.
• Is Part Of: Chemical science. Volume 8:Issue 2(2017)
• Page Start: 1002
• Page End: 1007
• Publication Date: 2016-11-08
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6sc04371b
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : We describe here a tandem catalytic route to prepare imidazoles in a single operation from aryl iodides, imines and CO. Abstract : We describe here a tandem catalytic route to prepare imidazoles in a single operation from aryl iodides, imines and CO. The reaction involves a catalytic carbonylation of aryl halides with imines to form 1, 3-dipoles, which undergo spontaneous 1, 3-dipolar cycloaddition. Overall, this offers an alternative to coupling reactions to construct the (hetero)aryl-imidazole motif, where variation of the building blocks can allow the synthesis of broad families of imidazoles with independent control of all substituents.