Why estrogens matter for behavior and brain health. (May 2017)
- Record Type:
- Journal Article
- Title:
- Why estrogens matter for behavior and brain health. (May 2017)
- Main Title:
- Why estrogens matter for behavior and brain health
- Authors:
- Galea, Liisa A.M.
Frick, Karyn M.
Hampson, Elizabeth
Sohrabji, Farida
Choleris, Elena - Abstract:
- Highlights: 17β-estradiol impacts specific cognitive and social behaviors in adult females. 17β-estradiol influences neuroprotection in models of stroke dependent on age. Estrone and 17β-estradiol differentially influence cognition and neuroplasticity. Experiential factors moderate cognitive outcome and neuroprotection with estrogens. Abstract: The National Institutes of Health (NIH) has required the inclusion of women in clinical studies since 1993, which has enhanced our understanding of how biological sex affects certain medical conditions and allowed the development of sex-specific treatment protocols. However, NIH's policy did not previously apply to basic research, and the NIH recently introduced a new policy requiring all new grant applications to explicitly address sex as a biological variable. The policy itself is grounded in the results of numerous investigations in animals and humans illustrating the existence of sex differences in the brain and behavior, and the importance of sex hormones, particularly estrogens, in regulating physiology and behavior. Here, we review findings from our laboratories, and others, demonstrating how estrogens influence brain and behavior in adult females. Research from subjects throughout the adult lifespan on topics ranging from social behavior, learning and memory, to disease risk will be discussed to frame an understanding of why estrogens matter to behavioral neuroscience.
- Is Part Of:
- Neuroscience and biobehavioral reviews. Volume 76:Part B(2017)
- Journal:
- Neuroscience and biobehavioral reviews
- Issue:
- Volume 76:Part B(2017)
- Issue Display:
- Volume 76, Issue 2 (2017)
- Year:
- 2017
- Volume:
- 76
- Issue:
- 2
- Issue Sort Value:
- 2017-0076-0002-0000
- Page Start:
- 363
- Page End:
- 379
- Publication Date:
- 2017-05
- Subjects:
- Psychophysiology -- Periodicals
Human behavior -- Periodicals
Animal behavior -- Periodicals
Neurology -- Periodicals
Behavior -- Periodicals
Ethology -- Periodicals
Neurology -- Periodicals
Psychophysiologie -- Périodiques
Comportement humain -- Périodiques
Animaux -- Mœurs et comportement -- Périodiques
Neurologie -- Périodiques
Animal behavior
Human behavior
Neurology
Psychophysiology
Periodicals
Electronic journals
573.8 - Journal URLs:
- http://www.sciencedirect.com/science/journal/01497634 ↗
http://www.elsevier.com/journals ↗ - DOI:
- 10.1016/j.neubiorev.2016.03.024 ↗
- Languages:
- English
- ISSNs:
- 0149-7634
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 6081.561000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 2640.xml