Regioselective Hydrodebromination of Polybrominated Indoles. Issue 18 (30th April 2014)

• Record Type: Journal Article
• Authors: Chelucci, Giorgio; Pinna, Gérard A.; Pinna, Giansalvo
• Is Part Of: European journal of organic chemistry. Issue 18(2014)
• Page Start: 3802
• Page End: 3807
• Publication Date: 2014-04-30
• Subjects: Synthetic methods -- Nitrogen heterocycles -- Bromine -- Reduction -- Palladium; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201400032
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: The mixture of sodium borohydride and N, N, N′, N′ ‐tetramethylethylenediamine in combination with a palladium catalyst is a mild and efficient system for the regioselective hydrodebromination of polybrominated indoles with both N ‐donating and N ‐withdrawing substituents [ N ‐methyl‐ and N ‐(methoxycarbonyl)indoles, respectively]. Abstract : The mixture of NaBH4 / N, N, N′, N′ ‐tetramethylethylenediamine in combination with a palladium catalyst is a mild and efficient system for the regioselective hydrodebromination of polybrominated indoles with both N ‐donating and N ‐withdrawing substituents [ N ‐methyl‐ and N ‐(methoxycarbonyl)indoles].