The effects of RAMPs upon cell signalling. (5th July 2017)

• Record Type: Journal Article
• Authors: Routledge, Sarah J.; Ladds, Graham; Poyner, David R.
• Is Part Of: Molecular and cellular endocrinology. Volume 449(2017)
• Page Start: 12
• Page End: 20
• Publication Date: 2017-07-05
• Subjects: Receptor activity modifying protein -- G protein-coupled receptor -- Signalling -- Trafficking -- Coupling; AM adrenomedullin -- AMY amylin -- CaSR calcium-sensing receptor -- CGRP calcitonin gene-related peptide -- CHO chinese hamster ovary -- CLR calcitonin receptor-like receptor -- CT calcitonin -- CTR calcitonin receptor -- CRF corticotrophin releasing factor -- ECD extracellular domain -- ECL extracellular loops -- GCGR glucagon receptor -- GLP glucagon-like peptide -- GLP, GLP2R glucagon-like peptide receptor 2 -- GPCR G protein-coupled receptor -- GPR30 G protein coupled estrogen receptor 1 -- GRKs G protein-coupled receptor kinases -- h human -- HEK human embryonic kidney -- m mouse -- NHERF-1 Na+/H+ exchanger regulatory factor-1 -- PTX pertussis toxin -- PTH parathyroid hormone -- PTHR parathyroid hormone receptor -- PTHrP parathyroid hormone related peptide -- r rat -- RAMP receptor activity modifying protein -- s salmon -- VPAC vasoactive intestinal peptide; Endocrinology -- Periodicals; Molecular biology -- Periodicals; Cytology -- Periodicals; Endocrinology -- Periodicals; Hormones -- Periodicals; Endocrinologie -- Périodiques; Cytology; Endocrinology; Molecular biology; Periodicals; 573.4
• DOI: 10.1016/j.mce.2017.03.033
• Languages: English
• ISSNs: 0303-7207

Abstract

Abstract: G protein-coupled receptors (GPCRs) play a vital role in signal transduction. It is now clear that numerous other molecules within the cell and at the cell surface interact with GPCRs to modulate their signalling properties. Receptor activity modifying proteins (RAMPs) are a group of single transmembrane domain proteins which have been predominantly demonstrated to interact with Family B GPCRs, but interactions with Family A and C receptors have recently begun to emerge. These interactions can influence cell surface expression, ligand binding preferences and G protein-coupling, thus modulating GPCR signal transduction. There is still a great deal of research to be conducted into the effects of RAMPs on GPCR signalling; their effects upon Family B GPCRs are still not fully documented, in addition to their potential interactions with Family A and C GPCRs. New interactions could have a significant impact on the development of therapeutics. Highlights: RAMPs have been shown to interact predominantly with Family B GPCRs, and recently with Family A and Family C GPCRs. RAMPs enhance trafficking to the cell surface of several GPCRs. RAMPs can alter GPCR signalling including enhancing coupling to certain G-proteins.