Anti-Pseudomonas aeruginosa IgG antibodies and chronic airway infection in bronchiectasis. (July 2017)

• Record Type: Journal Article
• Authors: Suarez-Cuartin, Guillermo; Smith, Alex; Abo-Leyah, Hani; Rodrigo-Troyano, Ana; Perea, Lidia; Vidal, Silvia; Plaza, Vicente; Fardon, Thomas C.; Sibila, Oriol; Chalmers, James D.
• Is Part Of: Respiratory medicine. Volume 128(2017)
• Page Start: 1
• Page End: 6
• Publication Date: 2017-07
• Subjects: Bronchiectasis -- Pseudomonas aeruginosa -- Antibody -- Chronic infection; Chest -- Diseases -- Periodicals; Chest -- Diseases -- Great Britain -- Periodicals; Respiratory organs -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Appareil respiratoire -- Maladies -- Périodiques; Thorax -- Maladies -- Périodiques; Appareil respiratoire -- Maladies -- Traitement -- Périodiques; Electronic journals; 616.2
• DOI: 10.1016/j.rmed.2017.05.001
• Languages: English
• ISSNs: 0954-6111

Abstract

Abstract: Background: Identification of chronic Pseudomonas aeruginosa (PA) infection is important in the management of bronchiectasis, but requires repeated sputum sampling. We hypothesized that serum anti-PA IgG antibodies could diagnose chronic PA infection at a single visit. Methods: Clinically stable bronchiectasis patients were studied prospectively. Chronic PA infection was defined as 2 or more positive sputum samples at least 3 months apart and/or failure to clear PA following eradication treatment. Baseline serum anti-PA IgG was determined by a validated ELISA kit. Results: A total of 408 patients were included. Sixty of them (14.7%) had chronic PA infection and had higher anti-PA IgG levels (median 6.2 vs. 1.3 units, p < 0.001). Antibody levels showed direct significant correlations with exacerbation frequency, the bronchiectasis severity index and sputum inflammatory markers. Fifty-seven patients with chronic PA infection had a positive test, giving 95% sensitivity, 74.4% specificity and AUROC of 0.87. During follow-up, 38 patients had a new PA isolation. Eradication at 12 months was achieved in 89.5% of subjects with a negative antibody test and 15.8% of patients with a positive test. Conclusions: Anti-PA IgG test is highly accurate to detect chronic PA infection in bronchiectasis patients. In addition, it may be a marker of disease severity and treatment response. Highlights: The anti-PA IgG test accurately detects chronic PA infection in bronchiectasis. Anti-PA IgG levels correlate with the activity of airway inflammatory biomarkers. The anti-PA IgG test may be a marker of disease severity and treatment response.