Vitamin D effects on B cell function in autoimmunity. (24th April 2014)

• Record Type: Journal Article
• Authors: Rolf, Linda; Muris, Anne‐Hilde; Hupperts, Raymond; Damoiseaux, Jan
• Other Names: Cutolo Maurizio guestEditor.; Straub Rainer H. guestEditor.; Masi Alfonse T. guestEditor.; Bijlsma Johannes W.J. guestEditor.
• Is Part Of: Annals of the New York Academy of Sciences. Volume 1317(2014)
• Page Start: 84
• Page End: 91
• Publication Date: 2014-04-24
• Subjects: vitamin D -- B cell function -- autoimmune diseases -- regulatory B cell -- interleukin‐10; Medical sciences -- Periodicals; Medicine -- Periodicals; Science -- Periodicals; 610
• DOI: 10.1111/nyas.12440
• Languages: English
• ISSNs: 0077-8923

Abstract

Abstract : Vitamin D seems to be implicated in the pathophysiology of autoimmune disorders as a natural immune modulator. Beneficial effects of vitamin D have been associated with different cells of the immune system; however, thus far, B cells seem to be somewhat neglected. In this paper, we describe the possible direct effects of vitamin D on B cells, with a focus on antibody production and the more recently identified regulatory B (Breg ) cells. B cells upregulate the vitamin D receptor (VDR) upon activation. Furthermore, due to regulated expression of the metabolizing enzymes CYP27B1 and CYP24A1, B cells have the potential to control the local availability of active vitamin D. B cells, therefore, may participate in vitamin D–mediated immune homeostasis, including plasma cell generation. Whether or not other B cell subsets, such as Breg cells, are equally responsive to vitamin D remains to be established.