Effect of fluorinated/non‐fluorinated β‐diketones and side‐chain branching of N‐protected amino acids on the antibacterial potential of new heptacoordinated monobutyltin(IV) complexes. (6th October 2016)

• Record Type: Journal Article
• Authors: Maheshwari, Karuna; Srivastava, Manish Kumar; Saxena, Sanjiv; Jain, Asha
• Is Part Of: Applied organometallic chemistry. Volume 31:Number 6(2017:Jun.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-10-06
• Subjects: antibacterial activity -- BuSnCl3 -- fluorinated β‐diketones -- heptacoordinated monobutyltin(IV) complexes -- non‐fluorinated β‐diketones -- N‐protected amino acids; Organometallic chemistry -- Periodicals; Organometallic compounds -- Periodicals; 547.05
• DOI: 10.1002/aoc.3628
• Languages: English
• ISSNs: 0268-2605

Abstract

Abstract : The effect of fluorinated/non‐fluorinated β‐diketones and side‐chain branching of N‐protected amino acids on the antibacterial potential of new heptacoordinated monobutyltin(IV) complexes was investigated. New heptacoordinated monobutyltin(IV) complexes having the general formulae BuSn(A)2 B and BuSnA(B)2 [where AH = (1, 3‐dihydro‐1, 3‐dioxo‐α‐(substituted)‐2 H ‐isoindole‐2‐acetic acids, N‐protected amino acids), R = CH(CH3 )CH2 CH3 : A1 H; R = CH(CH3 )2 : A2 H; and BH = R'COCH2 COR″ (β‐diketones), R′ = R″ = CH3 : B1 H; R′ = CH3, R″ = C6 H5 : B2 H; R′ = CF3, R″ = C6 H5 : B3 H] were synthesized. Complexes BuSn(A)2 B and BuSnA(B)2 were generated by the reaction of sodium salts of the ligands AH and BH with BuSnCl3 in 2:1:1 and 1:2:1 molar ratios, respectively. These newly generated complexes were characterized in physicochemical and spectroscopic studies. These complexes contain heptacoordinated tin centres as revealed by 119 Sn NMR chemical shift values. Some of the newly generated complexes and their corresponding ligands were screened for their antibacterial activity to study the structure–activity relationship. Abstract : Heptacoordinated complexes of the type BuSn(A)2 B and BuSnA(B)2 were synthesized. The effect of fluorinated/non‐fluorinated β‐diketones and side‐chain branching of N‐protected amino acids on the antibacterial potential of these complexes was investigated.