Quantifying antiepileptic drug effects using intrinsic excitability measures. (26th August 2016)
- Record Type:
- Journal Article
- Title:
- Quantifying antiepileptic drug effects using intrinsic excitability measures. (26th August 2016)
- Main Title:
- Quantifying antiepileptic drug effects using intrinsic excitability measures
- Authors:
- Meisel, Christian
Plenz, Dietmar
Schulze‐Bonhage, Andreas
Reichmann, Heinz - Abstract:
- Summary: Pathologic increases in excitability levels of cortical tissue commonly underlie the initiation and spread of seizure activity in patients with epilepsy. By reducing the excitability levels in neural tissue, antiepileptic drug (AED) pharmacotherapy aims to reduce seizure severity and frequency. However, AEDs may also bring about adverse effects, which have been reported to increase with higher AED load. Measures that monitor the dose‐dependent effects of AEDs on cortical tissue and quantify its excitability level are therefore of prime importance for efficient clinical care and treatment but have been difficult to identify. Here, we systematically analyze continuous multiday electrocorticography (ECoG) data from 10 patients under different levels of AED load and derive the recently proposed intrinsic excitability measures (IEMs) from different brain regions and across different frequency bands. We find that IEMs are significantly negatively correlated with AED load (prescribed daily dose/defined daily dose). Furthermore, we demonstrate that IEMs derived from different brain regions can robustly capture global changes in the degree of excitability. These results provide a step toward the ultimate goal of developing a reliable quantitative measure of central physiologic effects of AEDs in patients with epilepsy.
- Is Part Of:
- Epilepsia. Volume 57:issue 11(2016)
- Journal:
- Epilepsia
- Issue:
- Volume 57:issue 11(2016)
- Issue Display:
- Volume 57, Issue 11 (2016)
- Year:
- 2016
- Volume:
- 57
- Issue:
- 11
- Issue Sort Value:
- 2016-0057-0011-0000
- Page Start:
- e210
- Page End:
- e215
- Publication Date:
- 2016-08-26
- Subjects:
- Epilepsy -- Antiepileptic drug -- Biomarker -- Excitability
Epilepsy -- Periodicals
616.853 - Journal URLs:
- http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=epi ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1111/epi.13517 ↗
- Languages:
- English
- ISSNs:
- 0013-9580
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3793.700000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 2065.xml