Patient-reported outcomes in ductal carcinoma in situ: A systematic review. (January 2017)

• Record Type: Journal Article
• Authors: King, Madeleine T.; Winters, Zoë E.; Olivotto, Ivo A.; Spillane, Andrew J.; Chua, Boon H.; Saunders, Christobel; Westenberg, A. Helen; Mann, G. Bruce; Burnett, Petrina; Butow, Phyllis; Rutherford, Claudia
• Is Part Of: European journal of cancer. Volume 71(2017)
• Page Start: 95
• Page End: 108
• Publication Date: 2017-01
• Subjects: Anxiety -- Body image -- Carcinoma, intraductal, noninfiltrating -- Depression -- Pain -- Patient outcome assessment -- Quality of life -- Sexuality -- Stress, psychological; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Cancer; Tumors; Electronic journals; Periodicals; Electronic journals; 616.994
• DOI: 10.1016/j.ejca.2016.09.035
• Languages: English
• ISSNs: 0959-8049

Abstract

Abstract: Ductal carcinoma in situ (DCIS) is a pre-invasive breast cancer with excellent prognosis but with potential adverse impacts of diagnosis and treatment on quality of life and other patient-reported outcomes (PROs). We undertook a systematic review to synthesise current evidence about PROs following diagnosis and treatment for DCIS. We searched five electronic databases (from database inception to November 2015), cross-referenced and contacted experts to identify studies that reported PROs after DCIS treatment. Two reviewers independently applied inclusion and quality criteria, and extracted findings. Of 2130 papers screened, 23 were eligible, reporting 17 studies. Short- and long-term PRO evidence about differences between DCIS treatment options was lacking. Evidence pooled across treatments indicated core aspects of quality of life (physical, role, social, emotional function, pain, fatigue) and psychological distress (anxiety, depression) were impacted significantly initially, with most aspects returning to population norms by 6–12 months, and all by 2 years post-operatively. Fears of recurrence and dying from breast cancer were exaggerated, occurred early and persisted for many years. Sexuality and body image impacts were generally low and resolved within 1–3 months after surgery. A minority of women experienced considerable impact, including depression and sexual issues associated with body image problems. Well-powered PRO studies are required to track recovery trajectories and long-term impacts of the range of contemporary and emerging local and systemic treatments for DCIS. PRO data would enable care providers to prepare patients for short-term sequelae and enable patients who have treatment options to exercise preferences in choosing among them. Highlights: Treatment modalities for ductal carcinoma in situ affect patient-reported outcomes variably. Many aspects of quality of life are initially affected, but recover by 2 years. Fears of breast cancer recurrence and death are exaggerated and persistent. Depression, sexual and body image issues are uncommon, can be severe and co-occur. Evidence about differences in patient-reported outcomes between alternative ductal carcinoma in situ treatments is lacking.