Contrast enhanced renal MR angiography at 7 Tesla: How much gadolinium do we need?. Issue 86 (January 2017)

• Record Type: Journal Article
• Authors: Beiderwellen, Karsten; Kraff, Oliver; Laader, Anja; Maderwald, Stefan; Orzada, Stephan; Ladd, Mark E.; Forsting, Michael; Lauenstein, Thomas C.; Umutlu, Lale
• Is Part Of: European journal of radiology. Issue 86(2017)
• Page Start: 76
• Page End: 82
• Publication Date: 2017-01
• Subjects: BW body weight -- CR contrast ratio -- CTA computed tomography angiography -- DSA digital subtraction angiography -- FLASH fast low angle shot -- FOV field of view -- Gd gadolinium -- MR magnetic resonance -- MRA magnetic resonance angiography -- NSF nephrogenic systemic fibrosis -- T Tesla; Magnetic resonance imaging -- Contrast media -- Angiography -- Gadolinium -- Renal artery; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2016.11.007
• Languages: English
• ISSNs: 0720-048X

Abstract

Abstract: Objectives: To investigate whether a dose reduction of Gadobutrol for renal magnetic resonance angiography (MRA) at 7 Tesla (T) is feasible while preserving diagnostic image quality. Methods: Ten healthy volunteers were enrolled for a renal MRA on a 7 T scanner. Fast low angle shot (FLASH) MRA data sets were obtained utilizing three different doses of Gadobutrol (0.1, 0.05 and 0.025 mmol/kg body weight [BW]). Contrast ratios (CR) were measured in the aorta as well as in the intra- and extraparenchymal arteries compared to the psoas muscle. Qualitative analysis regarding the delineation of vessel structures was performed using a four-point-scale. Results: All doses of Gadobutrol allowed for a good delineation of the aorta and renal arteries. For the extra- and intraparenchymal segmental arteries higher values were observed for full and half dose in comparison to quarter dose. No significant difference was observed for full and half dose. A lower CR was observed for quarter compared to half dose (p < 0.05) for the renal arteries. Conclusions: While best results were observed for half and full dose, a dose reduction to 0.025 mmol/kg BW is justifiable, maintaining a diagnostic image quality. This may be of high interest considering patients with renal impairment.