Prenatal Diagnosis and Perinatal Outcomes of Congenital Megalourethra: A Multicenter Cohort Study and Systematic Review of the Literature. (7th October 2015)

• Record Type: Journal Article
• Authors: Moaddab, Amirhossein; Sananes, Nicolas; Hernandez-Ruano, Simone; Werneck Britto, Ingrid Schwach; Blumenfeld, Yair; Stoll, François; Favre, Romain; Ruano, Rodrigo
• Is Part Of: Journal of ultrasound in medicine. Volume 34:Number 11(2015)
• Page Start: 2057
• Page End: 2064
• Publication Date: 2015-10-07
• Subjects: anterior urethral valves -- congenital megalourethra -- fetal surgery -- lower urinary tract obstruction -- obstetric ultrasound -- posterior urethral valves -- urethral atresia; Ultrasonics in medicine -- Periodicals; Ultrasonics; Ultrasonography; Ultrasonics in medicine; Electronic journals; Periodicals; Periodicals; 616.07543
• DOI: 10.7863/ultra.14.12064
• Languages: English
• ISSNs: 0278-4297

Abstract

Abstract : Objectives: The purpose of this study was to evaluate the prenatal findings and postnatal outcomes in fetuses with congenital megalourethra. Methods: This retrospective study reviewed our experience and the literature between 1989 and 2014. Prenatal findings were evaluated and compared with postnatal findings, including neonatal mortality and abnormal renal function (need for dialysis or renal transplantation). Results: Fifty fetuses with congenital megalourethra were analyzed, including 6 cases diagnosed in our centers. Most cases (n = 43 [86.0%]) were diagnosed in the second trimester. Only 1 case was diagnosed in the first trimester, whereas 6 cases (12.0%) were diagnosed in the third trimester. Thirty‐five fetuses (70.0%) survived. Bilateral hydroureters were associated with perinatal death ( P = .024). Among the survivors, 41.9% of the neonates had renal impairment. The following factors were associated with postnatal renal impairment: presence of severe oligohydramnios/anhydramnios ( P = .033), bilateral hydronephrosis ( P = .008), and earlier gestational age at delivery ( P = .022). Conclusions: In fetal megalourethra, bilateral hydroureters, bilateral hydronephrosis, and severe oligohydramnios/anhydramnios are associated with neonatal mortality and renal impairment.