Influenza Evolution: New Insights into an Old Foe. Issue 6 (June 2017)

• Record Type: Journal Article
• Authors: Moncla, Louise H.; Florek, Nicholas W.; Friedrich, Thomas C.
• Is Part Of: Trends in microbiology. Volume 25:Issue 6(2017)
• Page Start: 432
• Page End: 434
• Publication Date: 2017-06
• Subjects: influenza -- evolution -- antibody -- antigenic drift; Microbiology -- Periodicals; Infection -- Periodicals; Virulence (Microbiology) -- Periodicals; Infection -- Periodicals; Microbiology -- Periodicals; Virulence -- Periodicals; Microbiologie -- Périodiques; Infection -- Périodiques; Virulence (Microbiologie) -- Périodiques; Infection; Microbiology; Virulence (Microbiology); 579
• DOI: 10.1016/j.tim.2017.04.003
• Languages: English
• ISSNs: 0966-842X

Abstract

Abstract : Influenza viruses steadily evolve to escape detection by antibodies, necessitating vaccine updates. A new study uses a massively parallel approach, deep mutational scanning, to catalogue antibody escape mutations. This approach defines potential pathways of viral evolution, beyond those already observed in natural infections, and may help predict its future directions.