Convenient one-pot synthesis of thiobarbituro-quinoline derivatives via catalyst-free multicomponent reactions in water. Issue 27 (5th July 2017)

• Record Type: Journal Article
• Authors: Kong, Dulin; Wang, Qinghe; Zhu, Zhongxiang; Wang, Xianghui; Shi, Zaifeng; Lin, Qiang; Wu, Mingshu
• Is Part Of: Tetrahedron letters. Volume 58:Issue 27(2017)
• Page Start: 2644
• Page End: 2647
• Publication Date: 2017-07-05
• Subjects: 2-Thiobarbituric acid -- 8-Quinolinol -- Synthesis -- Water; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2017.05.047
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: A green method for the synthesis of novel heterocyclic compounds is described. The protocol features free of organic solvents and catalysts, mild conditions. The reaction is suitable for large-scale operations. Abstract: A one-pot, three-component condensation reaction of 8-quinolinol, 2-thiobarbituric acid and isatins or aldehydes in water to give novel barbituroquinoline derivatives for the first time, is described. The reaction is free of catalysts and toxic solvents, operating under mild conditions and allows for ease of product isolation, making it more environmentally friendly and suitable for large-scale operations.