4Z- and 4E-12-deoxydihydrokromycins, two naturally occurring kromycin aglycones of pikromycin from Streptomyces sp. Issue 24 (14th June 2017)

• Record Type: Journal Article
• Authors: Yang, Inho; Yoon, Jisoo; Kim, Dayoung; Hahn, Dongyup; Nam, Sang-Jip; Fenical, William
• Is Part Of: Tetrahedron letters. Volume 58:Issue 24(2017)
• Page Start: 2322
• Page End: 2324
• Publication Date: 2017-06-14
• Subjects: Kromycin derivative -- Pikromycin aglycone -- Marine-derived Streptomyces sp. -- 14-Membered macrolide; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2017.03.088
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Streptomyces sp. CNT-189 was isolated from a Californian marine sediment. The culture media extracts yielded two naturally occurring kromycins. These kromycins may provide new building blocks for this class of macrolides. Abstract: HPLC–UV guided isolation for the culture broth extract of the marine-derived bacterium Streptomyces sp. has led to the two 14-membered macrolides, 4 Z - (1 ) and 4 E -12-dehydroxykromycins (2 ). The chemical structures of compounds1 and2 were elucidated by spectral data, while the absolute stereochemistry of1 and2 were determined by application of circular dichroism (CD) and analysis of X-ray crystallographic data.