One-pot copper-catalyzed synthesis of 2-substituted benzothiazoles from 2-iodoanilines, benzyl chlorides and elemental sulfur. Issue 24 (14th June 2017)

• Record Type: Journal Article
• Authors: Yang, Zhao; Hu, Renhe; Li, Xiaotong; Wang, Xin; Gu, Ren; Han, Shiqing
• Is Part Of: Tetrahedron letters. Volume 58:Issue 24(2017)
• Page Start: 2366
• Page End: 2369
• Publication Date: 2017-06-14
• Subjects: One-pot -- Copper-catalyzed -- Benzyl chloride -- 2-Substituted benzothiazoles; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2017.05.004
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: An efficient one-pot three-component reaction. The yield was up to 98%. Good functional group tolerance. Heterocycle methylene chlorides substrates were compatible for the reaction. Abstract: An efficient one-pot three-component reaction of 2-iodoanilines, benzyl chlorides and elemental sulfur to form 2-substituted benzothiazoles in satisfactory yields (up to 98%) has been described. The reaction tolerated a wide range of functional groups on the aromatic ring. And heterocycle methylene chlorides substrates were also found to be compatible.