N-alkylation of 2-pyridone derivatives via palladium(II)-catalyzed directed alkene hydroamination. Issue 26 (29th June 2017)
- Record Type:
- Journal Article
- Title:
- N-alkylation of 2-pyridone derivatives via palladium(II)-catalyzed directed alkene hydroamination. Issue 26 (29th June 2017)
- Main Title:
- N-alkylation of 2-pyridone derivatives via palladium(II)-catalyzed directed alkene hydroamination
- Authors:
- Gurak, John A.
Tran, Van T.
Sroda, Miranda M.
Engle, Keary M. - Abstract:
- Abstract: A selective N -alkylation reaction of 2-pyridones and related heterocycles via intermolecular alkene hydroamination is reported. The reaction utilizes palladium(II) acetate as a catalyst and employs a bidentate directing group to dictate the regioselectivity for both unactivated terminal and internal alkenes. High functional group tolerance is observed across a widerange of electronically diverse 2-pyridones and other aza-heterocycles, including 1-hydroxyisoquinoline, 2-hydroxyquinoline, pyridazinone, pyrimidinone, and pyrazinone. Graphical abstract:
- Is Part Of:
- Tetrahedron. Volume 73:Issue 26(2017)
- Journal:
- Tetrahedron
- Issue:
- Volume 73:Issue 26(2017)
- Issue Display:
- Volume 73, Issue 26 (2017)
- Year:
- 2017
- Volume:
- 73
- Issue:
- 26
- Issue Sort Value:
- 2017-0073-0026-0000
- Page Start:
- 3636
- Page End:
- 3642
- Publication Date:
- 2017-06-29
- Subjects:
- Alkenes -- Aza-heterocycles -- Directing group -- Hydroamination -- Palladium -- Pyridones (hydroxypyridines)
Chemistry, Organic -- Periodicals
547.005 - Journal URLs:
- http://www.elsevier.com/journals ↗
- DOI:
- 10.1016/j.tet.2017.03.091 ↗
- Languages:
- English
- ISSNs:
- 0040-4020
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8796.850000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 476.xml