Adoptive immunotherapy with genetically modified lymphocytes in allogeneic stem cell transplantation. Issue 1 (January 2014)

• Record Type: Journal Article
• Authors: Cieri, Nicoletta; Mastaglio, Sara; Oliveira, Giacomo; Casucci, Monica; Bondanza, Attilio; Bonini, Chiara
• Is Part Of: Immunological reviews. Volume 257:Issue 1(2014:Jan.)
• Page Start: 165
• Page End: 180
• Publication Date: 2014-01
• Subjects: allogeneic hematopoietic stem cell transplantation -- adoptive cellular immunotherapy -- gene therapy -- suicide gene -- TCR -- CAR; Immunology -- Periodicals; Transplantation of organs, tissues, etc -- Periodicals; 616.079
• DOI: 10.1111/imr.12130
• Languages: English
• ISSNs: 0105-2896

Abstract

Summary: Hematopoietic stem cell transplantation from a healthy donor (allo‐HSCT) represents the most potent form of cellular adoptive immunotherapy to treat malignancies. In allo‐HSCT, donor T cells are double edge‐swords: highly potent against residual tumor cells, but potentially highly toxic, and responsible for graft versus host disease (GVHD), a major clinical complication of transplantation. Gene transfer technologies coupled with current knowledge on cancer immunology have generated a wide range of approaches aimed at fostering the immunological response to cancer cells, while avoiding or controlling GVHD. In this review, we discuss cell and gene therapy approaches currently tested in preclinical models and in clinical trials. Video podcast available: Go to www.immunologicalreviews.com to watch an interview with Guest Editor Dr Carl June.