Metabolic reprogramming in cancer cells, consequences on pH and tumour progression: Integrated therapeutic perspectives with dietary lipids as adjuvant to anticancer treatment. (April 2017)

• Record Type: Journal Article
• Authors: Dumas, Jean-François; Brisson, Lucie; Chevalier, Stéphan; Mahéo, Karine; Fromont, Gaëlle; Moussata, Driffa; Besson, Pierre; Roger, Sébastien
• Is Part Of: Seminars in cancer biology. Volume 43(2017)
• Page Start: 90
• Page End: 110
• Publication Date: 2017-04
• Subjects: α-SMA α-smooth muscle actin -- AMPK AMP-activated protein kinase -- bHLH basic Helix-Loop-Helix -- DHA docosahexaenoic acid (22:6n-3) -- Drp1 dynamin-related protein 1 -- ECM extracellular matrix -- EMT epithelial-to-mesenchymal transition -- EPA eicosapentaenoic acid (20 5n-3) -- ERK1/2 extracellular signal-regulated kinase -- 18FdG 18-fluorodeoxyglucose -- 5-FU 5-fluorouracile -- HIF Hypoxia-Inducible Factor -- IFP interstitial fluid pressure -- LDH lactate dehydrogenase -- MAPK mitogen-activated protein kinase -- mCAT mitochondrial catalase -- MCT monocarboxylate-H+ co-transporter -- MDR multidrug resistance -- MMP matrix metalloproteinases -- n-3 PUFA n-3 polyunsaturated fatty acid -- NaV voltage-gated sodium channels -- NHE sodium-proton exchanger -- NMU N-nitroso-N-methylurea -- OXPHOS oxidative phosphorylation -- PDH pyruvate dehydrogenase -- PET positron emission tomography -- P-gp P-glycoprotein -- PPAR peroxisome proliferator activated receptor -- PPI proton pump inhibitor -- ROS reactive oxygen species -- TCA tricarboxylic acid cycle -- TMZ temozolomide -- UCP-2 mitochondrial uncoupling protein 2; Cancer cell metabolism -- pH -- Cancer cell invasiveness -- Resistance to treatments -- N-3 polyunsaturated fatty acids; Cancer -- Periodicals; Neoplasms -- Periodicals; Review Literature; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.semcancer.2017.03.004
• Languages: English
• ISSNs: 1044-579X

Abstract

Abstract: While tumours arise from acquired mutations in oncogenes or tumour-suppressor genes, it is clearly established that cancers are metabolic diseases characterized by metabolic alterations in tumour cells, and also non-tumour cells of the host organism resulting in tumour cachexia and patient weakness. In this review, we aimed at delineating details by which metabolic alterations in cancer cells, characterized by mitochondrial bioenergetics deregulations and the preference for aerobic glycolysis, are critical parameters controlling the aggressive progression of tumours. In particular, metabolic alteration in cancer cells are coupled to the modulation of intracellular and extracellular pH, epithelial-to-mesenchymal transition and associated increased invasiveness, autophagy, and the development of anticancer treatment resistance. Finally, based on mechanistic, pre-clinical and clinical studies, we proposed the adjuvant supplementation of dietary n-3 polyunsaturated fatty acids for a complementary holistic treatment of the cancer disease.