Environmental carcinogenesis and pH homeostasis: Not only a matter of dysregulated metabolism. (April 2017)

• Record Type: Journal Article
• Authors: Hardonnière, Kévin; Huc, Laurence; Sergent, Odile; Holme, Jørn A.; Lagadic-Gossmann, Dominique
• Is Part Of: Seminars in cancer biology. Volume 43(2017)
• Page Start: 49
• Page End: 65
• Publication Date: 2017-04
• Subjects: AhR aryl hydrocarbon receptor -- B[a]P benzo[a]pyrene -- CYP cytochrome P450 -- EMT epithelial-to-mesenchymal transition -- Cx43 connexin 43 -- GJIC gap junction intercellular communication -- HMGCoA reductase 3-hydroxy-3-methylglutaryl-CoA reductase -- NHE1 Na+/H+ exchanger 1 -- PAH polycyclic aromatic hydrocarbon -- pHi intracellular pH -- pHe extracellular pH -- TCA cycle tricarboxylic acid cycle -- TCDD 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin -- ΔΨm mitochondrial membrane potential -- Δp proton motive force -- ΔpHm cytosol-mitochondrial proton gradient; pH and carcinogenesis -- Benzo[a]pyrene -- Na+/H+ exchanger -- Apoptosis -- Warburg effect; Cancer -- Periodicals; Neoplasms -- Periodicals; Review Literature; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.semcancer.2017.01.001
• Languages: English
• ISSNs: 1044-579X

Abstract

Abstract: According to the World Health Organization, around 20% of all cancers would be due to environmental factors. Among these factors, several chemicals are indeed well recognized carcinogens. The widespread contaminant benzo[a]pyrene (B[a]P), an often used model carcinogen of the polycyclic aromatic hydrocarbons' family, has been suggested to target most, if not all, cancer hallmarks described by Hanahan and Weinberg. It is classified as a group I carcinogen by the International Agency for Research on Cancer; however, the precise intracellular mechanisms underlying its carcinogenic properties remain yet to be thoroughly defined. Recently, the pH homeostasis, a well known regulator of carcinogenic processes, was suggested to be a key actor in both cell death and Warburg-like metabolic reprogramming induced upon B[a]P exposure. The present review will highlight those data with the aim of favoring research on the role of H + dynamics in environmental carcinogenesis.