Helical Polyisocyanopeptides as Lyotropic Liquid Crystals for Measuring Residual Dipolar Couplings. Issue 32 (15th May 2017)

• Record Type: Journal Article
• Authors: Li, Gao‐Wei; Cao, Jiang‐Ming; Zong, Wen; Hu, Li; Hu, Mao‐Lin; Lei, Xinxiang; Sun, Han; Tan, Ren Xiang
• Is Part Of: Chemistry. Volume 23:Issue 32(2017)
• Page Start: 7653
• Page End: 7656
• Publication Date: 2017-05-15
• Subjects: liquid crystals -- NMR spectroscopy -- polyisocyanodipeptides -- residual dipolar couplings -- small organic molecules; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201700539
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: Residual dipolar couplings (RDC) emerged to be an important structural parameter for organic and biomolecules. Herein, a new helical polyisocyanopeptide (l, l ‐PIAF‐OBn) that forms lyotropic liquid crystals (LLC) in CDCl3 is proposed as a novel weakly orienting medium for acquiring residual dipolar couplings (RDCs) of organic molecules. We demonstrate its application for the structural elucidation of strychnine and triptolide. Abstract : A helical polyisocyanopeptide (l, l ‐PIAF‐OBn) can form lyotropic liquid crystal phases and adopts a strikingly low critical concentration in chloroform. The adjustable alignment medium is easily manipulated and allows the acquisition of residual dipolar couplings (RDCs) for organic molecules.