Analysis of serum corticosteroid‐induced alkaline phosphatase isoenzyme in dogs with hepatobiliary diseases. (30th January 2017)

• Record Type: Journal Article
• Authors: Kojima, K.; Ohno, K.; Kanemoto, H.; Goto‐Koshino, Y.; Fukushima, K.; Tsujimoto, H.
• Is Part Of: Journal of small animal practice. Volume 58:Number 5(2017)
• Page Start: 257
• Page End: 262
• Publication Date: 2017-01-30
• Subjects: Veterinary medicine -- Periodicals; Veterinary Medicine -- Periodicals; 636.089
• DOI: 10.1111/jsap.12623
• Languages: English
• ISSNs: 0022-4510

Abstract

Abstract : Objective : To reveal the relationship between canine corticosteroid‐induced alkaline phosphatase isoenzyme activity and hepatobiliary diseases. Materials and Methods : Retrospective analysis of the relationship between serum corticosteroid‐induced alkaline phosphatase activity and diagnosis, serum cortisol concentration and alanine transferase activity in dogs with hepatobiliary diseases. Dogs with a history of glucocorticoid administration were excluded. Results : Seventy‐two dogs with hepatobiliary diseases were analysed. The serum corticosteroid‐induced alkaline phosphatase concentration was increased in dogs with hepatobiliary diseases. There was no correlation between serum cortisol concentration and serum corticosteroid‐induced alkaline phosphatase percentage or activity. Clinical Significance : Dogs with hepatobiliary disease can exhibit high serum alkaline phosphatase activity even if the dogs have not been administrated glucocorticoids and the serum cortisol concentration is normal.