Synthesis of the N‐Substituted Pyridin‐1(2H)‐one Framework by Ligand‐Assisted Pd‐Catalyzed Reactions. Issue 3 (30th November 2012)

• Record Type: Journal Article
• Authors: Zhou, Kang; Wen, Ping; Chen, Wenlin; Ma, Chaowei; Huang, Guosheng
• Is Part Of: European journal of organic chemistry. Issue 3(2013)
• Page Start: 448
• Page End: 452
• Publication Date: 2012-11-30
• Subjects: Nitrogen heterocycles -- Palladium -- Reactions mechanisms -- Synthetic methods; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201201151
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: An efficient Pd‐catalyzed method for the synthesis of N ‐substituted pyridin‐1(2 H )‐ones was developed. The corresponding derivatives, which can be found in numerous biologically active compounds, were obtained in good to excellent yields. A possible mechanism for this reaction is discussed. Abstract : An efficient ligand‐assisted palladium‐catalyzed approach for the straightforward synthesis of the pyridin‐2(1 H )‐one framework was developed. This method provides one of the easiest pathways to access this class of valuable compounds from easily available starting materials (2‐chloropyridines). A possible mechanism for this reaction is discussed.