Serum polyunsaturated fatty acid metabolites as useful tool for screening potential biomarker of colorectal cancer. (May 2017)

• Record Type: Journal Article
• Authors: Zhang, Li-jian; Chen, Bin; Zhang, Jun-jie; Li, Jian; Yang, Qingjing; Zhong, Qi-sheng; Zhan, Song; Liu, Huwei; Cai, Chun
• Is Part Of: Prostaglandins, leukotrienes, and essential fatty acids. Volume 120(2017)
• Page Start: 25
• Page End: 31
• Publication Date: 2017-05
• Subjects: LA Linoleic acid -- AA Arachidonic acid -- IS Internal standard -- LOX Lipoxygenase -- COX Cyclooxygenase -- CYP450 Cytochrome P450 -- HODE hydroxyl-octadecadienoic acid -- KODE oxo-octadecadienoic acid -- Tetranor-PGEM tetranor-prostaglandin E metabolite -- TX thromboxane -- HETE hydroxyl-eicosatetraenoic acids -- LT leukotriene -- LX lipoxin -- DiHETE dihydroxy-eicosatetraenoic acid -- HpETE hydroperoxy-eicosatetraenoic acid -- DHET dihydroxy-eicosatrienoic acid -- EET epoxy-eicosatrienoic acid -- HpEPE hydroperoxy eicosapentaenoic acid -- PG prostaglandin -- CRC colorectal cancer -- PUFA polyunsaturated fatty acid -- HpODE hydroperoxy-octadecadienoic acid; Lipidomic -- Colorectal cancer -- Ultra-high performance liquid chromatography -- Mass spectrometry; Lipids -- Periodicals; Unsaturated fatty acids -- Periodicals; Prostaglandins -- Periodicals; Leukotrienes -- Periodicals; Fatty Acids, Unsaturated -- Periodicals; Acides gras insaturés -- Périodiques; Prostaglandines -- Périodiques; Leucotriènes -- Périodiques; Lipides -- Périodiques; 612.01577
• DOI: 10.1016/j.plefa.2017.04.003
• Languages: English
• ISSNs: 0952-3278

Abstract

Abstract: The biomarker identification of cancer is benefit for early detection and less invasion. Polyunsaturated fatty acid (PUFA) metabolite as inflammatory mediators can affect progression and treatment of cancer. In this work, the serum was collected from colorectal cancer patients and healthy volunteers, and then we tested the change of serum PUFA metabolites in both of them by ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). Of the 158 PUFA and their metabolites, we found that abnormal change of 2, 3-dinor-8-iso-PGF2α, 19-HETE and 12-keto-LTB4 from arachidonic acid were observed in colorectal cancer patients. Meanwhile, 9-HODE and 13-HODE from linoleic acid were significant lower in colorectal cancer patients. Our data suggested that some PUFA metabolites might be used as a potential biomarker of colorectal cancer, which might provide assistance in clinical diagnosis and treatment. Highlights: 158 PUFA and their metabolites in serum were analyzed by UPLC-MS/MS. Serum lipidome give me a comprehensive map of PUFAs metabolite in the process of CRC. Five PUFA metabolites were used as a potential biomarker of CRC.