Toll-like receptor activation, vascular endothelial function, and hypertensive disorders of pregnancy. (July 2017)

• Record Type: Journal Article
• Authors: Balasubbramanian, Dakshnapriya; Gelston, Catalina A. Lopez; Mitchell, Brett M.; Chatterjee, Piyali
• Is Part Of: Pharmacological research. Volume 121(2017:Jul.)
• Page Start: 14
• Page End: 21
• Publication Date: 2017-07
• Subjects: AngII angiotensin II -- APCs antigen presenting cells -- Aza azathioprine -- CO carbon monoxide -- DAMPs danger-associated molecular patterns -- DOCA deoxycorticosterone acetate -- dsRNA double-stranded RNA -- EDHF endothelial-derived hyperpolarizing factor -- ET-1 endothelin-1 -- HO heme oxygenase -- IFN interferon -- IL interleukin -- IRF interferon regulatory factor -- MMF mycophenolate mofetil -- NF-kappaB nuclear factor kappa B -- NO nitric oxide -- NOD nucleotide-binding oligomerization domain-like -- PAMPs pathogen-associated molecular patterns -- P pregnant -- PDGF platelet-derived growth factor -- PE preeclampsia -- PIC polyinosinic:polycytidylic acid -- PlGF placental-derived growth factor -- PLX-PAD placental expanded cells (Pluristem Therapeutics Inc.) -- PRR pattern recognition receptor -- r recombinant -- R R-837 -- ROS reactive oxygen species -- RUPP reduced uterine perfusion pressure -- sEng soluble endoglin -- sFlt-1 soluble fms-like tyrosine kinase-1 -- SHR spontaneously hypertensive rat -- ssRNA single-stranded RNA -- TGF-beta, transforming growth factor beta -- TLR Toll-like receptor -- Tregs, regulatory T cells -- Th helper T cell -- TxA2 thromboxane receptor A2 -- VEGF vascular endothelial growth factor -- VSMC vascular smooth muscle cell -- vWF von Willebrand factor; Endothelial dysfunction -- Inflammation -- Artery -- Toll-like receptor -- Preeclampsia -- Pregnancy; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2017.04.018
• Languages: English
• ISSNs: 1043-6618

Abstract

Graphical abstract: Abstract: Aberrant innate immune system activation in the mother contributes greatly to the development of hypertension during pregnancy. Numerous groups have elicited vascular inflammation, endothelial dysfunction, and hypertension in animals during gestation by directly activating Toll-like receptors. Additionally, several experimental therapies that reduce pro-inflammatory immune cells and cytokines restore vascular endothelial function and normalize blood pressure. This review will summarize the research demonstrating that an excessive maternal innate immune response is sufficient to cause vascular inflammation and endothelial dysfunction, which contributes to the development of hypertension during pregnancy. Dampening the vascular inflammation caused by immune responses may reduce the incidence and severity of hypertensive disorders of pregnancy.