A novel framework for understanding reduced awareness of dyskinesias in Parkinson's Disease. (June 2017)

• Record Type: Journal Article
• Authors: Palermo, Sara; Lopiano, Leonardo; Zibetti, Maurizio; Rosato, Rosalba; Leotta, Daniela; Amanzio, Martina
• Is Part Of: Parkinsonism & related disorders. Volume 39(2017)
• Page Start: 58
• Page End: 63
• Publication Date: 2017-06
• Subjects: Parkinson's disease -- Dyskinesias -- Self-awareness -- Theory of Mind -- Reading the Mind in the Eyes; Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2017.03.009
• Languages: English
• ISSNs: 1353-8020

Abstract

Abstract: Background: Although dyskinesias-reduced-self-awareness (DRSA) in Parkinson's disease (PD) is related to deficit in metacognition, other factors, such as "Theory of Mind" (ToM), could operate. Methods: Forty-one PD patients were assessed using the Global Awareness of Movement Disorders (GAM) and the Dyskinesias Subtracted-Index (DS-I). To study whether GAM and DS-I scores could be influenced by second-type ToM or Reading the Mind in the Eyes (RME) tasks, we conducted two multiple logistic regression analyses. Results: The association between the GAM, the DS-I and RME task were highly significant. The association between DS-I and Trail Making Test B-A version was also verified. Conclusion: DRSA was related with affective component of ToM and executive functions, thus caused by a complex interplay between specific neuropsychological and motor factors. Highlights: Dyskinesias are common motor complications in Parkinson's disease (PD). PD patients can show dyskinesias-reduced-self-awareness (DRSA). We analyzed the association between DRSA and Theory of Mind (ToM). We found evidence that DRSA was related with affective ToM and executive functions. DRSA is caused by a complex interplay between neuropsychological and motor factors.