Differential regenerative ability of sensory and motor neurons. (23rd June 2017)

• Record Type: Journal Article
• Authors: Cheah, Menghon; Fawcett, James W.; Haenzi, Barbara
• Is Part Of: Neuroscience letters. Volume 652(2017)
• Page Start: 35
• Page End: 40
• Publication Date: 2017-06-23
• Subjects: Spinal cord -- Regeneration -- Sensory neurons -- Motor neurons -- Grafts; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2016.11.004
• Languages: English
• ISSNs: 0304-3940

Abstract

Abstract: After injury, the adult mammalian central nervous system (CNS) lacks long-distance axon regeneration. This review discusses the similarities and differences of sensory and motor neurons, seeking to understand how to achieve functional sensory and motor regeneration. As these two types of neurons respond differently to axotomy, growth environment and treatment, the future challenge will be on how to achieve full recovery in a way that allows regeneration of both types of fibres simultaneously.