Assessments of sensory plasticity after spinal cord injury across species. (23rd June 2017)

• Record Type: Journal Article
• Authors: Haefeli, Jenny; Huie, J. Russell; Morioka, Kazuhito; Ferguson, Adam R.
• Is Part Of: Neuroscience letters. Volume 652(2017)
• Page Start: 74
• Page End: 81
• Publication Date: 2017-06-23
• Subjects: CSF cerebrospinal fluid -- NHP nonhuman primate -- NP neuropathic pain -- QST quantitative sensory testing -- SCI spinal cord injury -- USV ultrasonic vocalization; Common data elements -- Spinal cord injury -- Pain -- Sensory assessment; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2016.12.031
• Languages: English
• ISSNs: 0304-3940

Abstract

Abstract: Spinal cord injury (SCI) is a multifaceted phenomenon associated with alterations in both motor function and sensory function. A majority of patients with SCI report sensory disturbances, including not only loss of sensation, but in many cases enhanced abnormal sensation, dysesthesia and pain. Development of therapeutics to treat these abnormal sensory changes require common measurement tools that can enable cross-species translation from animal models to human patients. We review the current literature on translational nociception/pain measurement in SCI and discuss areas for further development. Although a number of tools exist for measuring both segmental and affective sensory changes, we conclude that there is a pressing need for better, integrative measurement of nociception/pain outcomes across species to enhance precise therapeutic innovation for sensory dysfunction in SCI.