The role of the TOR pathway in mediating the link between nutrition and longevity. (June 2017)

• Record Type: Journal Article
• Authors: Lushchak, Oleh; Strilbytska, Olha; Piskovatska, Veronika; Storey, Kenneth B.; Koliada, Alexander; Vaiserman, Alexander
• Is Part Of: Mechanisms of ageing and development. Volume 164(2017)
• Page Start: 127
• Page End: 138
• Publication Date: 2017-06
• Subjects: TOR target of rapamycin -- TSC tuberous sclerosis complex -- Rheb Ras homologue enriched in brain -- 4EBP 4E binding protein -- S6K S6 kinase -- PI3K phosphatidylinositol-3-kinase -- Raptor regulatory-associated protein of mTOR -- Deptor DEP domain-containing mTOR-interacting protein -- SREBP1/2 sterol regulatory element-binding protein 1/2 -- IGF insulin-like growth factor -- TNFα tumor necrosis factor α -- PDCD4 programmed cell death 4 -- HIF1α hypoxia inducible factor α -- DR dietary restriction -- YY1 Ying-Yang 1 -- SIRT1 silent information regulator 1 -- AMPK adenosine monophosphate-activated protein kinase; Aging -- Lifespan -- Nutrition -- Rapamycin -- TOR signaling pathway; Aging -- Periodicals; Developmental biology -- Periodicals; Aging -- Periodicals; Developmental Biology -- Periodicals; Vieillissement -- Périodiques; Biologie du développement -- Périodiques; Aging; Developmental biology; Periodicals; 612.67
• DOI: 10.1016/j.mad.2017.03.005
• Languages: English
• ISSNs: 0047-6374

Abstract

Highlights: The conserved TOR signaling pathway links internal and external signals to various cellular processes. Deprivation of nutrients is an important determinant of TOR activity. Dietary interventions affect lifespan and activity of the TOR pathway. Rapamycin and metformin realize anti-aging effect via regulation of TOR. Abstract: The target of rapamycin (TOR) pathway integrates signals from extracellular and intracellular agents, such as growth factors, nutrients, mediators of energy balance, oxygen availability and other environmental cues. It allows the regulation of multiple cellular processes including protein and lipid synthesis, ribosome biogenesis, autophagy and metabolic processes. Being conserved across different phyla, TOR regulates longevity of various organisms in response to dietary conditions. In this review we described the main components of the TOR pathway and its upstream effectors and downstream processes in relation to aging. The potential contribution of the TOR pathway in lifespan-extending effects of varied dietary interventions, and the anti-aging drugs rapamycin and metformin direct or indirect regulation of TOR activity in yeasts, worms, flies and mammals are also discussed.