Interleukin-6 and interleukin-10 gene polymorphisms and their plasma level after polytrauma. (2017)

• Record Type: Journal Article
• Authors: Sapan, Heber B.; Paturusi, Idrus; Jusuf, Irawan; Patellongi, Ilhamjaya; Massi, Nasrum; Hatta, Mochammad; Pusponegoro, Aryono D.; Arief, Syafrie K.; Labeda, Ibrahim; Islam, Andi A.; Rendy, Leo
• Is Part Of: International journal of surgery open. Volume 7(2017)
• Page Start: 5
• Page End: 9
• Publication Date: 2017
• Subjects: Surgery -- Periodicals; 617.005
• DOI: 10.1016/j.ijso.2017.04.001
• Languages: English
• ISSNs: 2405-8572

Abstract

Highlights: Interaction of two main cytokines (IL-6 and IL-10) after major trauma comes from the mRNA expression of IL-6 and IL-10 gene. Severe injury with tendency to endure multiple organ dysfunction syndrome after trauma is ISS>40. Surviving patients had higher IL-6/IL-10 ratio compared with the same severe trauma patients who did not survived. Immune response greater than this lead to immune system failure and the end of spectrum is multi-organ failure and death. There is correlation between IL-10 gene polymorphism (592C/A) and MODS after polytrauma.