Inflammatory response after nailing. (June 2017)

• Record Type: Journal Article
• Authors: Kanakaris, Nikolaos K.; Anthony, Christopher; Papasotiriou, Antonios; Giannoudis, Peter V.
• Is Part Of: Injury. Volume 48(2017)Supplement 1
• Page Start: S10
• Page End: S14
• Publication Date: 2017-06
• Subjects: ALI acute lung injury -- ARDS acute respiratory distress syndrome -- CARS compensatory anti-inflammatory response syndrome -- CD-11 cluster of differentiation molecule 11 -- CRP c-reactive protein -- DAMPs damage-associated molecular patterns -- FES fat embolism syndrome -- HLA-DR human leucocyte antigens – antigen D related -- IL interleukin -- LBP lipopolysaccharide binding protein -- MODS multiple organ distress syndrome -- MOF multiple organ failure -- PAMPs pathogen associated molecular patterns -- PCT procalcitonin -- s-ICAM-1 soluble intercellular adhesion molecule- 1 -- SIRS systemic inflammatory response syndrome -- TNF tumor necrosis factor; Intramedullary nailing -- Reaming -- Immune response -- Cytokines -- SIRS -- CARS; Wounds and injuries -- Surgery -- Periodicals; Accidents -- Periodicals; Wounds and Injuries -- surgery -- Periodicals; Lésions et blessures -- Chirurgie -- Périodiques; Electronic journals; Electronic journals; 617.1
• DOI: 10.1016/j.injury.2017.04.017
• Languages: English
• ISSNs: 0020-1383

Abstract

Abstract: Intramedullary nailing, as the gold standard stabilisation method of most long bones, has been tailed by its extensive use as the basic tool of investigating the immune response to trauma in many large and small animal models, as well as at the clinical setting. Over the last few decades a complex map of interactions between pro and anti-inflammatory pathways has been the result of these significant global research efforts. Parallel to the evolution of modern nailing and reaming techniques, significant developments at the fields of other disciplines relevant to trauma care, has improved the contemporary management of injured patients, challenging previous concepts and altering clinical barriers. The current article aims to summarise the current understanding of the effect of instrumenting the medullary canal after trauma, and hint on potential future directions.