Cornelian cherry consumption increases the l-arginine/ADMA ratio, lowers ADMA and SDMA levels in the plasma, and enhances the aorta glutathione level in rabbits fed a high-cholesterol diet. (July 2017)

• Record Type: Journal Article
• Authors: Sozański, Tomasz; Kucharska, Alicja Z.; Szumny, Dorota; Magdalan, Jan; Merwid-Ląd, Anna; Nowak, Beata; Piórecki, Narcyz; Dzimira, Stanisław; Jodkowska, Anna; Szeląg, Adam; Trocha, Małgorzata
• Is Part Of: Journal of functional foods. Volume 34(2017)
• Page Start: 189
• Page End: 196
• Publication Date: 2017-07
• Subjects: ADMA asymmetric dimethylarginine -- DDAH dimethylarginine dimethylaminohydrolase -- MDA malondialdehyde -- ELISA enzyme-linked immunosorbent assay -- eNOS endothelial nitric oxide synthase -- HPLC high-performance liquid chromatography -- PPARα peroxisome proliferator-activated receptor alpha -- PRMTs protein arginine methyltransferases -- RONS reactive oxygen and nitrogen species -- SDMA symmetric dimethylarginine -- TNFα tumor necrosis factor α; Cornelian cherry -- ADMA -- SDMA -- l-arginine -- DDAH -- Oxidative stress -- MDA -- Glutathione; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2017.04.028
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: Cornelian cherry fruits increase the L-arginine/ADMA ratio in the plasma. Cornelian cherry fruits decrease ADMA and SDMA levels in the plasma. Cornelian cherry fruits enhance DDAH activity in the liver. Cornelian cherry fruits diminish local redox stress in the aorta. Cornelian cherry fruits decrease intima thickness in the thoracic aorta. Abstract: In our previous publication we showed that the oral administration of cornelian cherry fruits prevented feed-induced atherosclerosis. In this study we have examined the effect of cornelian cherry lyophilisate on proteins responsible for regulation of NO synthesis: asymmetric and symmetric dimethylarginine (ADMA, SDMA) andl -arginine in plasma, and dimethylarginine dimethylaminohydrolase (DDAH) in the liver. We have also assessed the systemic and local redox status in the blood and the aorta, and the thickness of the thoracic aorta. We have shown that 60-days of administering lyophilisate to rabbits fed 1% cholesterol increased thel -arginine andl -arginine/ADMA ratio, decreased ADMA and SDMA, increased DDAH activity, and had a positive impact on the redox state in the aorta but not in the blood, measured as decreased MDA, and increased glutathione, GPx, and SOD. Moreover, lyophilisate significantly decreased intima thickness and the intima/media ratio in the thoracic aorta. Concluding, thel -arginine-ADMA-DDAH pathway may contribute to the beneficial effects of the cornelian cherry in feed-induced atherosclerosis.