An effective peptide cargo carrier for the delivery of cisplatin in ovarian cancer cells. (August 2017)

• Record Type: Journal Article
• Authors: Lai, Yanhua; Zhao, Ping; Zhang, Zhan; Li, Bai; Wu, Junchen
• Is Part Of: Dyes and pigments. Volume 143(2017)
• Page Start: 342
• Page End: 347
• Publication Date: 2017-08
• Subjects: Peptide cargo carrier -- Targeted delivery -- Cisplatin -- Ovarian cancer -- Disassembly; Dyes and dyeing -- Periodicals; Pigments -- Periodicals; 667.2
• DOI: 10.1016/j.dyepig.2017.04.025
• Languages: English
• ISSNs: 0143-7208

Abstract

Abstract: The self-assembled peptide cargo carrier with the ability of probe offered an effective strategy to deliver and track the anticancer drug, cisplatin (DDP) in ovarian cancer cells. This simple peptide system containing a pyrene fluorogen and arginine-glycine-aspartic acid (RGD) sequence could be utilized to release DDP in situ by the specific recognition between an RGD motif and αv β3 integrin that was over-expressed on ovarian cancer cells. Importantly, we found that the disassembly-triggered peptide nanofibers, PA1, could effectively combine with DDP and release DDP in the cytoplasm with the pyrene fluorescence restoring. Moreover, the peptide cargo carrier efficiently penetrated tumour cells for enhancing therapeutic efficacy. Our system could open the door for the delivery of anticancer drug in cancer-related therapy. Graphical abstract: The self-assembled peptide cargo carrier with the ability of probe offered an effective strategy to deliver and track the anticancer drug, cisplatin (DDP) in ovarian cancer cells. Highlights: This simple peptide system containing a pyrene fluorogen and arginine-glycine-aspartic acid (RGD) sequence could be utilized to release DDP in situ. The peptide cargo carrier efficiently penetrated tumour cells for enhancing therapeutic efficacy.