Vitamin K status in cystic fibrosis patients with liver cirrhosis. Issue 6 (June 2017)

• Record Type: Journal Article
• Authors: Krzyżanowska, Patrycja; Drzymała-Czyż, Sławomira; Pogorzelski, Andrzej; Duś-Żuchowska, Monika; Skorupa, Wojciech; Bober, Lyudmyla; Sapiejka, Ewa; Oralewska, Beata; Rohovyk, Nataliya; Moczko, Jerzy; Nowak, Jan; Wenska-Chyży, Ewa; Rachel, Marta; Lisowska, Aleksandra; Walkowiak, Jarosław
• Is Part Of: Digestive and liver disease. Volume 49:Issue 6(2017)
• Page Start: 672
• Page End: 675
• Publication Date: 2017-06
• Subjects: Fat-soluble vitamin -- Hepatology diseases -- Prothrombin inducted by vitamin K absence-II -- Undercarboxylated osteocalcin; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; 616.33005
• DOI: 10.1016/j.dld.2017.01.155
• Languages: English
• ISSNs: 1590-8658

Abstract

Abstract: The available data on the influence of liver cirrhosis on vitamin K status in CF patients is scarce. Therefore, the aims of the present study were to assess the prevalence of vitamin K deficiency in cirrhotic CF subjects and to determine whether it correlates with liver cirrhosis. The study group comprised of 27 CF patients with and 63 without liver cirrhosis. Vitamin K status was assessed using prothrombin induced by vitamin K absence (PIVKA-II) and the percentage of undercarboxylated osteocalcin (u-OC). PIVKA-II concentrations were higher in cirrhotic than in non-cirrhotic CF patients (median [1st–3rd quartile]: 3.2 ng/ml [1.0–10.0] vs. 1.3 ng/ml [0.2–2.6], p = 0.0029). However, the differences in u-OC percentages between the studied groups did not reach the level of significance (49.4% [7.0–73.8] vs. 8.0% [2.6–59.1], p = 0.0501). Based on multiple linear regression analysis the dose of vitamin K and F508del mutation were potentially defined as determinants of vitamin K deficiency. Liver cirrhosis was not documented to be an independent risk factor. In CF patients with liver cirrhosis vitamin K deficiency is not only more frequent, but also more severe. However, not liver cirrhosis, but the presence of a F508del CFTR mutation constitutes an independent risk factor for vitamin K deficiency.