Renal clear cell carcinoma: diffusion tensor imaging diagnostic accuracy and correlations with clinical and histopathological factors. Issue 7 (July 2017)

• Record Type: Journal Article
• Authors: Feng, Q.; Fang, W.; Sun, X.P.; Sun, S.H.; Zhang, R.M.; Ma, Z.J.
• Is Part Of: Clinical radiology. Volume 72:Issue 7(2017)
• Page Start: 560
• Page End: 564
• Publication Date: 2017-07
• Subjects: Medical radiology -- Periodicals; Radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiology -- Periodicals; Societies, Medical -- Periodicals; Medical radiology; Radiotherapy; Electronic journals; Periodicals; 616.0757
• DOI: 10.1016/j.crad.2017.02.016
• Languages: English
• ISSNs: 0009-9260

Abstract

Abstract : Aim: To investigate whether diffusion tensor imaging (DTI) can be used to assess renal clinical histopathology, including the nuclear grade (NG), cell density (CD), and the presence of ki-67. Materials and methods: Thirty patients were enrolled in the study and were confirmed at surgical histopathology to have clear cell renal cell carcinoma (CCRCC). For DTI, a coronal echo-planar imaging sequence was performed (1400 ms repetition time, 76 ms echo time, diffusion direction=6, number of excitations=4; b=0 and 800 s/mm 2, 6 mm section thickness with no intersection gap). CD and the presence of ki-67 were compared between the different NGs. Correlations between apparent diffusion coefficients (ADCs), E1, fractional anisotropy (FA), CD, and ki-67 were evaluated. Results: ADC, E1, and FA values are important tools used to identify NG. The cut-off values were 1.003×10 −3 mm 2 /s, 1.277×10 −3 mm 2 /s, and 0.218 mm 2 /s, respectively. The difference between high- and low-grade CD was significant ( t =−4.50, p <0.05). Similarly, a significant difference between high and low grade was also found in ki-67 ( t =−4.03, p <0.05). ADC, E1, and FA values were decreased with increased CD; a significant negative correlation was found ( r =−0.796, −0.865, and −0.996, respectively). Significant negative correlations between ADC, E1, and FA values, and ki-67 were found ( r =−0.739, −0.826, and −0.876, respectively). Conclusions: DTI can be used to non-invasively assess CCRCC. Highlights: DTI can evaluate cell density and presence of ki-67 ADC, E1, and FA values can be used to identify NG. ADC, E1, FA and CD, ki-67 were negatively correlated. Identification of renal tumour characteristics is helpful for adequate treatment.