Biofilms and host response – helpful or harmful. Issue 4 (April 2017)

• Record Type: Journal Article
• Authors: Moser, Claus; Pedersen, Hannah Trøstrup; Lerche, Christian Johann; Kolpen, Mette; Line, Laura; Thomsen, Kim; Høiby, Niels; Jensen, Peter Østrup
• Other Names: Calum Henrik guestEditor.; Moser Claus guestEditor.
• Is Part Of: Apmis. Volume 125:Issue 4(2017:Apr.)
• Page Start: 320
• Page End: 338
• Publication Date: 2017-04
• Subjects: Biofilm infections -- innate immunity -- adaptive immunity -- inflammation -- neutrophils -- cystic fibrosis -- chronic wounds -- infective endocarditis; Pathology -- Periodicals; Microbiology -- Periodicals; Immunology -- Periodicals; 572
• DOI: 10.1111/apm.12674
• Languages: English
• ISSNs: 0903-4641

Abstract

Abstract : Biofilm infections are one of the modern medical world's greatest challenges. Probably, all non‐obligate intracellular bacteria and fungi can establish biofilms. In addition, there are numerous biofilm‐related infections, both foreign body‐related and non‐foreign body‐related. Although biofilm infections can present in numerous ways, one common feature is involvement of the host response with significant impact on the course. A special characteristic is the synergy of the innate and the acquired immune responses for the induced pathology. Here, we review the impact of the host response for the course of biofilm infections, with special focus on cystic fibrosis, chronic wounds and infective endocarditis.