The role of STIM1 and SOCE in smooth muscle contractility. (May 2017)

• Record Type: Journal Article
• Authors: Feldman, C.H.; Grotegut, C.A.; Rosenberg, P.B.
• Is Part Of: Cell calcium. Volume 63(2017)
• Page Start: 60
• Page End: 65
• Publication Date: 2017-05
• Subjects: Stromal interaction molecule 1 (STIM1) -- Store-operated calcium entry -- Store-operated calcium channels -- Smooth muscle contraction; Ca2+ calcium -- CSM cavernous smooth muscle -- CPA cyclopiazonic acid -- [Ca2+] icytoplasmic calcium concentration -- GoF gain of function -- GI gastrointestinal -- LoF loss of function -- ROCC sreceptor-operated calcium channels -- S/ER sarco(endo)plasmic reticulum -- SCID severe-combined immunodeficiency -- STIM1 stromal interaction molecule 1 -- SOCC sstore-operated calcium channels -- SOCE store-operated calcium entry -- TG thapsigargin -- VSM vascular smooth muscle -- VOCC svoltage-operated calcium channels; Calcium -- Metabolism -- Periodicals; Vertebrates -- Physiology -- Periodicals; Calcium -- Physiological effect -- Periodicals; Cell physiology -- Periodicals; Calcium in the body -- Periodicals; 572.516
• DOI: 10.1016/j.ceca.2017.02.007
• Languages: English
• ISSNs: 0143-4160

Abstract

Abstract: Contraction is a central feature for skeletal, cardiac and smooth muscle; this unique feature is largely dependent on calcium (Ca 2+ ) signaling and therefore maintenance of internal Ca 2+ stores. Stromal interaction molecule 1 (STIM1) is a single-pass transmembrane protein that functions as a Ca 2+ sensor for the activation store-operated calcium channels (SOCCs) on the plasma membrane in response to depleted internal sarco(endo)plasmic (S/ER) reticulum Ca 2+ stores. STIM1 was initially characterized in non-excitable cells; however, evidence from both animal models and human mutations suggests a role for STIM1 in modulating Ca 2+ homeostasis in excitable tissues as well. STIM1-dependent SOCE is particularly important in tissues undergoing sustained contraction, leading us to believe STIM1 may play a role in smooth muscle contraction. To date, the role of STIM1 in smooth muscle is unknown. In this review, we provide a brief overview of the role of STIM1-dependent SOCE in striated muscle and build off that knowledge to investigate whether STIM1 contributes to smooth muscle contractility. We conclude by discussing the translational implications of targeting STIM1 in the treatment of smooth muscle disorders.