Prolonged QT interval is linked to all‐cause and cardiac mortality in chronic peritoneal dialysis patients. Issue 6 (June 2017)

• Record Type: Journal Article
• Authors: Kuo, Huey‐Liang; Liu, Yao‐Lung; Liang, Chih‐Chia; Chang, Chiz‐Tzung; Wang, Su‐Ming; Liu, Jiung‐Hsiun; Lin, Hsin‐Hung; Wang, I‐Kuan; Yang, Ya‐Fei; Chou, Che‐Yi; Huang, Chiu‐Ching
• Is Part Of: Nephrology. Volume 22:Issue 6(2017)
• Page Start: 436
• Page End: 440
• Publication Date: 2017-06
• Subjects: cardiac mortality -- mortality -- peritoneal dialysis -- QT interval; Nephrology -- Periodicals; Kidneys -- Diseases -- Periodicals; Nephrologists -- Periodicals; 616.61; 616.61
• DOI: 10.1111/nep.12808
• Languages: English
• ISSNs: 1320-5358

Abstract

Abstract: Aim: Prolonged QT interval is related to changes of electrolytes in haemodialysis (HD) and is associated with all‐cause mortality in HD patients. It is unknown if prolonged QT interval is associated with all‐cause mortality in peritoneal dialysis (PD) patients as the electrolytes were relatively stable in PD. We therefore investigated the association of prolonged QT interval and all‐cause mortality in chronic PD patients. Methods: The QT intervals were measured in 2003 and all patients were followed to December 2012. A prolonged QT interval was defined as a QT interval > 450 ms. The association of prolonged QT interval with all‐cause and cardiac‐specific mortality was analyzed using Cox regression and Kaplan–Meier analysis. Results: Of 306 patients, 196 (64%) patients had prolonged QT interval. The incidence density rate was 9.7 per 100 persons‐years for all‐cause mortality and 5.6 for cardiac specific mortality in patients with prolonged QT interval. Prolonged QT interval was associated with all‐cause mortality with a hazard ratio (HR) of 1.59 (95% confidence interval (CI): 1.06–2.39, P = 0.03] and cardiac mortality (HR: 1.66, 95% CI: 1.00–2.78, P = 0.05) with adjustments for age, gender, diabetes, and vintage of dialysis. Longer QT interval (>500 ms, 450–500 ms, and < 450 ms) was significantly associated with a worse overall survival ( P = 0.03, log‐rank test) and cardiac mortality free survival ( P = 0.05, log‐rank test). Conclusions: Prolonged QT interval was associated with all‐cause and cardiac mortality in patients on peritoneal dialysis. The association is independent of patient's age and diabetes. Summary at a Glance: The study (NEP‐2016‐0045.R3 ) aimed to examine 10 year all‐cause mortality and CV mortality in association to prolonged QT interval, in peritoneal dialysis patients. Prolonged QT interval is associated with higher overall mortality and cardiac mortality in patients receiving peritoneal dialysis. The association is independent of patient's age and diabetes.