Subchronic toxicity of low dose propoxur, permethrin, and their combination on the redox status of rat liver. (25th June 2017)

• Record Type: Journal Article
• Authors: Wang, Pan; Xu, Ming-Yuan; Liang, Yu-Jie; Wang, Hui-Ping; Sun, Ying-Jian; Long, Ding-Xin; Wu, Yi-Jun
• Is Part Of: Chemico-biological interactions. Volume 272(2017)
• Page Start: 21
• Page End: 27
• Publication Date: 2017-06-25
• Subjects: Pesticide -- Hepatotoxicity -- Pyrethroids -- Carbamates -- Joint effects; Biochemistry -- Periodicals; Toxicological chemistry -- Periodicals; Biochemistry -- Periodicals; Biologie moléculaire -- Périodiques; Biochimie -- Périodiques; Toxicologie biochimique -- Périodiques; 572
• DOI: 10.1016/j.cbi.2017.04.023
• Languages: English
• ISSNs: 0009-2797

Abstract

Abstract: Carbamates and pyrethroids are widely used pesticides. However, their joint toxicity at low doses with long-term exposure remains unknown. Therefore, we investigated the subchronic joint hepatotoxicity of the two representative pesticides within these two classes, i.e., propoxur (PR) and permethrin (PE) in rats. The male Wistar rats were orally treated with three different doses of PR, PE and their mixtures for 90 consecutive days. Liver weight, serum clinical chemistry parameters and histopathological changes were measured to access the hepatotoxicity. In addition, oxidative stress markers in liver were measured using biochemical assays. The results showed that PR reduced liver weight and lead to prominent liver histological changes. Moreover, PR dose-dependently induced lipid peroxidation and reduced superoxide dismutase activity. In contrast, PE induced a relatively mild hepatotoxicity. Intriguingly, the mixture of PR and PE did not reduce liver weight or increase serum aspartate transaminase activity. In addition, the mixture did not reduce the antioxidant enzyme activity as PR did. Thus, these results showed that PR induced prominent hepatotoxicity with subchronic exposure, and there is a potential antagonistic interaction between PR and PE on the oxidative damage in liver of rats. Highlights: Mixtures of propoxur (PR) and permethrin (PE) induced oxidative stress in rat liver. Lipids were sensitive to the oxidative damage by PR and PE. PR and PE displayed antagonistic interaction on the induction of lipid peroxidation.