Chemistry of 2-cyanomethylene-4-thiazolidinone. (4th May 2017)

• Record Type: Journal Article
• Authors: El-Gaby, Mohamed S. A.; Ammar, Yousry A.; El-Hag Ali, Gameel A. M.; Helal, Mohamed H. M.; Salem, Mohamed A.; Ghorab, Mostafa M.
• Is Part Of: Journal of sulfur chemistry. Volume 38:Number 3(2017)
• Page Start: 314
• Page End: 345
• Publication Date: 2017-05-04
• Subjects: 4-Thiazolidinone -- thiazolo[3, 2-a]pyridine -- pyrano[2, 3-d]- thiazole;[1, 2, 3]triazine -- [1, 8]naphthyridine; Sulfur -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.72305
• DOI: 10.1080/17415993.2016.1263304
• Languages: English
• ISSNs: 1741-5993

Abstract

ABSTRACT: This article is a brief review about the synthesis and chemistry of 2-cyanomethylene-4-thiazolidinone1 . The most significant applications of 4-thiazolidinone1 in heterocyclic synthesis are due to its two reactive methylenes. The endo-cyclic methylene protons are activated by the neighboring carbonyl moiety and the exo-cyclic methylene protons by the adjacent cyano group. Different types of reactions, such as alkylation, coupling, and Knoevenagel condensation, as well as cyclization reactions are illustrated for the synthesis of different classes of biologically important heterocyclic skeletons from this novel precursor. GRAPHICAL ABSTRACT: