Covalent Probe Finds Carboxylic Acid. Issue 5 (18th May 2017)

• Record Type: Journal Article
• Authors: Jones, Alexander; Zhang, Xiaoyun; Lei, Xiaoguang
• Is Part Of: Cell chemical biology. Volume 24:Issue 5(2017)
• Page Start: 537
• Page End: 539
• Publication Date: 2017-05-18
• Subjects: Biochemistry -- Periodicals; 572.05
• DOI: 10.1016/j.chembiol.2017.05.003
• Languages: English
• ISSNs: 2451-9456

Abstract

Abstract : In this issue of Cell Chemical Biology, Martín-Gago et al. (2017a) disclose a new strategy for the selective covalent targeting of binding site carboxylic acids within the proteome using the isoxazolium salt as a warhead. This discovery paves the way for developing new protein ligation methods as well as covalent drug candidates. Abstract : In this issue of Cell Chemical Biology, Martín-Gago et al. (2017a) disclose a new strategy for the selective covalent targeting of binding site carboxylic acids within the proteome using the isoxazolium salt as a warhead. This discovery paves the way for developing new protein ligation methods as well as covalent drug candidates.