Flavanonol glucosides from the aerial parts of Agrimonia pilosa Ledeb. and their acetylcholinesterase inhibitory effects. (5th June 2017)

• Record Type: Journal Article
• Authors: Seo, U. Min; Nguyen, Duc Hung; Zhao, Bing Tian; Min, Byung Sun; Woo, Mi Hee
• Is Part Of: Carbohydrate research. Volume 445(2017)
• Page Start: 75
• Page End: 79
• Publication Date: 2017-06-05
• Subjects: Agrimonia pilosa -- Flavanonol glucoside -- Acetylcholinesterase activity; Carbohydrates -- Periodicals; Chemistry, Organic -- Periodicals; Biochemistry -- Periodicals; Carbohydrates -- Periodicals; Chimie organique -- Périodiques; Glucides -- Périodiques; Biochemistry; Carbohydrates; Chemistry, Organic; Periodicals; Electronic journals; 507.78
• DOI: 10.1016/j.carres.2017.04.014
• Languages: English
• ISSNs: 0008-6215

Abstract

Abstract: Two new flavanonol glucoside isomers, (2 R, 3 S )-dihydrokaempferol 3- O - β -D-glucoside (1 ) and (2 S, 3 R )-dihydrokaempferol 3- O - β -D-glucoside (2 ), were isolated from the aerial parts of Agrimonia pilosa Ledeb., along with eight known flavanonol glucosides (3 –10 ). Their structures were determined on the basis of spectroscopic analysis. In addition, these compounds were evaluated to determine their acetylcholinesterase inhibitory activities. The results indicated that these compounds have moderate inhibitory effects, with IC50 values ranging from 76.59 ± 1.16 to 97.53 ± 1.64 μM, except compounds1 and4 were inactive. Graphical abstract: Highlights: Two new flavanonol glucoside isomers and eight known compounds were isolated from Agrimonia pilosa Ledeb. Their structures were determined on the basis of spectroscopic analysis. All isolated compounds were evaluated for their AChE inhibitory activities. Most of isolates showed moderate inhibitory effects.