Synthesis and biological evaluation of novel 5-aryl-4-(5-nitrofuran-2-yl)-pyrimidines as potential anti-bacterial agents. Issue 13 (1st July 2017)

• Record Type: Journal Article
• Authors: Verbitskiy, Egor V.; Baskakova, Svetlana A.; Gerasimova, Natal'ya A.; Evstigneeva, Natal'ya P.; Zil'berberg, Natal'ya V.; Kungurov, Nikolay V.; Kravchenko, Marionella A.; Skornyakov, Sergey N.; Pervova, Marina G.; Rusinov, Gennady L.; Chupakhin, Oleg N.; Charushin, Valery N.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 27:Issue 13(2017)
• Page Start: 3003
• Page End: 3006
• Publication Date: 2017-07-01
• Subjects: Pyrimidine -- Nitrofuran -- Antigonorrheal -- Antimycobacterial -- Nucleophilic aromatic substitution of hydrogen; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2017.05.013
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: A facile two-step synthetic approach to fluorinated and non-fluorinated 5-aryl-4-(5-nitrofuran-2-yl)-pyrimidines from readily available 5-bromo-4-(furan-2-yl)pyrimidine has been developed. All synthesized compounds were screened in vitro for their antibacterial activities against twelve various bacterial strains. It is demonstrated that some of these compounds exhibited significant antibacterial activities against strains Neisseria gonorrhoeae and Staphylococcus aureus, comparable and even higher with that commercial drug Spectinomycin.